Thank you for your inquiry and interest in ChemPoint. If youd like my help or recipes for this bleaching cream please contact me on Instagram @kaylinell and @kay.linell or Facebook at kay linell. Cite this article. 20grams ofhydroquinonein 20oz is liquid is 10%. hydroquinone, 1,4-benzenediol, quinol, 1,4-dihydroxybenzene, p-benzenediol, 4-hydroxyphenol, p-hydroquinone, p-hydroxyphenol, p-dihydroxybenzene, benzoquinol, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, Chemical Storage and Management Resource Center, Solubility in water: 70g/L in water (20C). V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= Stir until uniform. S.C. Gad, T. Pham, in Encyclopedia of Toxicology (Third Edition), 2014 Environmental Fate and Behavior. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. trailer << /Size 393 /Info 347 0 R /Root 375 0 R /Prev 573815 /ID[<6893db2526a970a0c364cca2e99ca522>] >> startxref 0 %%EOF 375 0 obj << /Type /Catalog /Pages 346 0 R /Metadata 348 0 R >> endobj 391 0 obj << /S 2217 /Filter /FlateDecode /Length 392 0 R >> stream Hydroquinone is soluble in alcohol solvents such as ethanol and methanol [17]. The natural pH for conventional hydroquinone compositions is acidic, generally less than about 4 even though this is harsh to the skin and to other components of the product. If youre making your lotion. The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. uv curable cellulose estersuv curable cellulose esters . . Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. RJPT - Hydroquinone Solubility in Pure and Binary Solvent Mixture at Some documentation and label information may refer to the legacy brand. Also in this embodiment is a cationic salt of acidic ascorbyl esters, which further helps to maintain the acceptable color desired in the hydroquinone composition. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25K to 334.45K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. Formula of hydroquinone is . All information collection is solely used to support ChemPoint customers service communications. You can expect to hear from a technical specialist within 1 business hour. You take the cream, put it in a container, take the powder measurement and add it. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. ChemPoint will not under any circumstances release personal user information to individuals or companies. Part of Springer Nature. Chem. Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. [O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1, OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE, CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O, [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] dihydrogen phosphate, [Na+]. The protective system can be an entrapment system, a single or multi-laminar system, such as by formation of vesicle, such as a liposome, or by utilizing wax, paraffin, silicone, polyethylene or any material or system which protects the retinoid from oxidation. However, these hydroquinone-containing compositions were in the acidic pH range and did not contain cationic salts of acidic ascorbyl esters, such as magnesium ascorbyl phosphate. Ferulic acid 0.5% 0.15g. Hydroquinone occurs as fine, white needles. By clicking Accept, you consent to the use of cookies. Please sign in to view account pricing and product availability. J. The 10 Best Hydroquinone Creams to Buy in 2023 - Beauty Mag Solubility of Hydroquinone : r/OrganicChemistry I would like to add retinol and kojic acid to it as well. 88, 161164 (2010), J. Delgado, Int. The disodium diphenolate salt of hydroquinone is used as an alternating comonomer unit in the production of the polymer PEEK. Hydroquinone - an overview | ScienceDirect Topics Other solubilities: soluble in alcohol and ether,slightly soluble in benzene,readily soluble in ethanol,acetone and methanol, Needle-like Crystals or Crystalline Powder. A specific embodiment of the invention is listed in the following table. . 1401417, Country of ref document: The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and . Hydrquinone Cas N: 123-31-9 - Oecd For a shipping quote, check the box and the bottom and provide us your shipping information. Anal. Environ. Such carriers are widely known in the art and deliver the composition's ingredients to the skin without excessive degradation, inactivation or other unwanted interaction. Will glycerol and citric acid react? If yes, under what conditions? Antioxidants in the hydroquinone phase are instrumental in stabilizing the color of the hydroquinone composition. It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Learn more about Institutional subscriptions, C. M. S. de Mendona, I. P. de Barros Lima, C. F. S. Arago, A. P. B. Gomes, J. Therm. The solubility was increased by addition of ethanol, reached a maximum . It is also used to prepare 2% bleaching creams and certain intermediates for the synthesis of dyes, and it has some activity as an antitumoragent. If you are already a ChemPoint customer then sign up for access to our online ordering website. vitamin C; Salts thereof, Medicinal preparations containing active ingredients not provided for in groups A61K31/00-A61K41/00, Mixtures of active ingredients without chemical characterisation, e.g. Data 51, 16681671 (2006), C. L. Yaws, S.-C. Lin, Enthalpy of fusion at freezing pointOrganic compounds, in Thermophysical Properties of Chemicals and Hydrocarbons, William Andrew Publishing (Elsevier, 2009), pp. Hydroquinone Safety Data Sheet according to Federal Register / Vol. 43, 13111316 (2007), J. Qing-Zhu, M. Pei-Sheng, Z. Huan, X. Shu-Qian, W. Qiang, Q. Yan, Fluid Phase Equilib. x- [ 0}y)7ta>jT7@t`q2&6ZL?_yxg)zLU*uSkSeO4?c. R -25 S>Vd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L` "AYA+Cb(R, *T2B- 0000085850 00000 n Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. The Campaign for Safe Cosmetics has also highlighted concerns. The protective system can be an entrapment system, a single or multi- laminar system, such as by the formation of vesicles such as a liposome or by utilizing wax, paraffin, silicone, polyethylene, or any material or system which protects the retinoid from oxidation. The solubility of sodium phenytoin in binary mixtures of ethanol +water at 298.2, 303.2, 308.2 and 313.2 K was measured. Solubility of Hydroquinone in Different Solvents from 276.65 K to 345. Hydroquinone can be made through several routes. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25 K to 334.45 K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. In 1-octanol, the decreasing order of the solubility of these compounds is as follows: resorcinol>benzoic acid>salicylic acid>hydroquinone. 0000005306 00000 n EP2047846A2 - Process for stabilizing hydroquinone - Google This website uses cookies. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. How do I dissolve hydroquinone powder to make a 20% and 10% concentration? 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. https://doi.org/10.1007/s10765-020-02750-4. G(DC:!c?5w [QDP, f\01j&8ea]Ke~z d _5H^j0M.|Y^bYb[Rm~-[ImSv. ;4kNNw?r yn^EOwCDyd>_?TU^vyss*|g9A1 avr 2o~molpb|CZTu(70 CKRu)(5O_^6|Qta', uG70]'vt|n3Xh[vMTc.{o0Y#(O5\/mGfI+L0~1E1~hi:ZY_W6n*EaSn*R+I)Pw|y\^/te;yO. 0000005757 00000 n 0000003660 00000 n [27] Several such agents are already available or under research,[28] including azelaic acid,[29] kojic acid, retinoids, cysteamine,[30] topical steroids, glycolic acid, and other substances. Glycerol and citric acid, non-toxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90-150C. 0000008514 00000 n fungichromin, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. 57, 295300 (2013), R. F. Pires, M. R. Franco Jr, Fluid Phase Equilib. D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. Phase A: Dissolve L-Ascorbic Acid in distilled water via agitation and gentle heating (warm, never hot or you will denature the ascorbic acid). Eng. I'm using it for spot treatment of some hyper pigmentation (less than 1% of my body). Thermodyn. A3, Free format text: The Molecular Weight is 110.11 g/mol. 2023 Springer Nature Switzerland AG. Obagi Nu-Derm Clear (Hydroquinone USP, 4%) Skin Bleaching Cream Obagi Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. In the United States, the most commonly used treatment for hyperpigmentation is 1,4-benzenediol, which is known as hydroquinone. Since the neutral pH of the hydroquinone composition with sodium metabisulfite and magnesium ascorbyl phosphate is preferably from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, the pH is acceptable for also including retinoids in the composition. [31], Hydroquinones are one of the two primary reagents in the defensive glands of bombardier beetles, along with hydrogen peroxide (and perhaps other compounds, depending on the species), which collect in a reservoir. 322, 4855 (2012), K. Tamura, T. Kasuga, T. Nakagawa, Fluid Phase Equilib. As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. https://doi.org/10.1007/s10765-020-02750-4, DOI: https://doi.org/10.1007/s10765-020-02750-4. P, Kind code of ref document: The solubility in water is 6.72g/L. It is moderately soluble in water and highly soluble in alcohol. ;O,1Y+%8#oKT^VWtew4>@V.SR :hmBZ>#ey!UC5! / /n Chem. Other properties of hydroquinone are given in Table 1. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals. [32], Hydroquinone is thought to be the active toxin in Agaricus hondensis mushrooms. Approved only for prescription use in the U.S. market.Ideal for creams, lotions, and gels for personal care ingredients, pharmaceutical chemical, pharmaceutical excipients, and skin care ingredients. The experimental solubility data was well-correlated with the data, calculated by . Your document download will begin shortly. What is Hydroquinone: Properties, Uses and Applications, Examples 0000005089 00000 n Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. Preferably, the protected retinoid, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), is in the form of small beads or spheres suitable for incorporation into a topical composition. I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. Then add it to the ingredients. Hydroquinone: Environmental Pollution, Toxicity, and Microbial Answers This chamber is lined with cells that secrete catalases and peroxidases. Consistent with a condensation reaction, water was determined to be the primary byproduct. Water Solubility 73000 mg/L at 25C 2.6B pH pKa 4.0 - 4.7 pK1 = 9.9 2.12 Oxidation:Reduction Potential +286 mV at 25C and pH 7 ENVIRONMENTAL FATE/BIODEGRADATION This compound is gathered from the beaver's castor sacs.[35]. 2008-2023 ChemPoint. Place water in container then bring the temperature to 15c in a boil bath then add products at this point when youre making the lotion u will need to add the other ingredients. A2, Designated state(s): It has a white-solid appearance. 374 0 obj << /Linearized 1 /O 376 /H [ 807 1414 ] /L 581425 /E 96582 /N 109 /T 573826 >> endobj xref 374 19 0000000016 00000 n I can only tell you how to mix the powder solution to the liquid solvent. International Journal of Thermophysics 0000004433 00000 n endstream endobj 277 0 obj <>stream SAS Anti-ox booster 1% 0.3g. When the contents of the reservoir are forced into the reaction chamber, the catalases and peroxidases rapidly break down the hydrogen peroxide and catalyze the oxidation of the hydroquinones into p-quinones. [Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O, trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane, C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1, C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C, 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine, CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC, 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1, O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C, [Na+].[Na+].[Na+]. Can be destroyed by oxidizing it with an oxidizing mixture. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. 420, 2429 (2016), W. E. Acree Jr, Thermochim Acta 189, 3756 (1991), F. L. Nordstrm, . C. Rasmuson, J. Chem. This saturated dicarboxylic acid exists as a white powder. Preparation, optimization and in vivo. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. endstream endobj 1 0 obj <> endobj 2 0 obj <> endobj 12 0 obj <>stream 114, 175188 (1996), I. Hahnenkamp, G. Graubner, J. Gmehling, Int. 0000002221 00000 n I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 77, No. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. 2017-02-16T10:10:56+01:00 Pigmentation disorders can take a variety of forms like hyperpigmentation and hypopigmentation, such as melasma (dark patches experienced in pregnancy), liver spots (which often develop with age), as a side effect of birth control pills, and as a persistent result of acne, bums, bites and other skin injuries, and vitiligo. Hydrogen peroxide is used and the reaction gives a mixture of hydroquinone and catechol: An accessible route involves the reaction of sodium hydroxide with 1,4-dichlorobenzene. Google Scholar, A.-C. Huang, Y.-K. Chuang, C.-F. Huang, C.-M. Shu, J. Therm. PDF HYDROQUINONE - Centers for Disease Control and Prevention Hydroquinone IS a white crystalline substance when pure and is highly soluble in water. Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Solute (1 g) Water Boiling Water Alcohol Chloroform Ether Other Acenocoumarol 67,000 280 130 1800 Acetaminophen 20 10 1 N sodium hydroxide, 15 Acetohexamide 230 210 Acetylcysteine 5 4 Acetyldigitoxin 6100 62.5 12 >10,000 Ammonium Alum 7 0.5 Aluminum Chloride 0.9 4 Aluminum Sulfate 1 Amantadine Hydrochloride 2.5 5.1 18 polyethylene glycol 400, 70 Reddit and its partners use cookies and similar technologies to provide you with a better experience. It is a major component in most black and white photographic developers for film and paper where, with the compound metol, it reduces silver halides to elemental silver. Hydroquinone - Sciencemadness Wiki Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. The present invention combats this problem, with hydroquinone compositions in the neutral pH range, preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. volume42, Articlenumber:1 (2021) The document was not able to download due to an unknown error. On this Wikipedia the language links are at the top of the page across from the article title. Exceptional antioxidant qualities are seen at 0.10% (all percentages in the application are weight percent) and above, preferably from about 0.05% to about 0.5% for sodium metabisulfite. [Na+].OC[C@H](O)[C@H]1OC([O-])=C(OP([O-])([O-])=O)C1=O, N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1, C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21, CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, [Na+]. 2y.-;!KZ ^i"L0- @8(r;q7Ly&Qq4j|9 Azelaic acid (AzA) is a organic compound with the formula HOOC(CH 2) 7 COOH. The reservoir opens through a muscle-controlled valve onto a thick-walled reaction chamber. Classical photo shops also sell hydroquinone. If you have any specific questions, please include them in the comments section. English, J.C. and Deisinger, P.J. 0000053439 00000 n Color stability improvement is evident at all levels. 0.5% magnesium ascorbyl phosphate protected at pH 6.0-7.0, 1.0-1.5% at pH 5.5-7.0, and 2.0-3.0% at pH 3.5-7.0. This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. 58 / Monday, March 26, 2012 / Rules and Regulations 10/31/2017 EN (English US) 6/8 12.3. SOLUBILITIES - DrugFuture This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. C6H4O2) is formed. PDF Solubilityof Eastman hydroquinone andderivatives Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. J. Pharm. A common route involves hydroxylation of phenol. Solubility of Hydroquinone in Different Solvents from - ResearchGate Stabilisation of biofuels with hydrophilic, natural antioxidants We apologize! Other aspects, advantages, and modifications are evident from a review of the following claims. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. This is seen at about a pH of 3.50 with at least about 2.0% magnesium ascorbyl phosphate, and again at a pH of about 6.5 to about 7.0 with at least about 2.0% magnesium ascorbyl phosphate. 4]DYR@'c Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Best Budget Hydroquinone Cream Ambi Skincare Fade Cream (56g/2oz) View on Amazon. While patients suffer from pigmentation disorders, they may also suffer from other skin disorders and signs of aging, including but not limited to rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. M1 and M2 microemulsions contain ethanol as co-surfactant. 0000003430 00000 n Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. This composition is color stabilized and cosmetically elegant.